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MCQ for Full Syllabus Biology Molecular Basis of Inheritance
Full Syllabus Biology students should refer to the following multiple-choice questions with answers for Molecular Basis of Inheritance in Full Syllabus.
Molecular Basis of Inheritance MCQ Questions Full Syllabus Biology with Answers
Question: Haploid content of human DNA contains
- a) 3.3 × 109 bp
- b) 6.6 × 109 bp
- c) 3.3 × 108 bp
- d) 4.6 × 106 bp
Answer: 3.3 × 109 bp
Question: Which of the following nitrogenous bases are common for both RNA and DNA?
- a) C, G, A
- b) G, A, U
- c) T, A, C
- d) U, A, C
Answer: C, G, A
Question: Adjacent nucleotides in a polynucleotide chain are joined by
- a) Phosphodiester bond
- b) O-glycosidic bond
- c) Hydrogen bond
- d) N-glycosidic bond
Answer: Phosphodiester bond
Question: Sugars are attached to the pyrimidines by the formation of
- a) N-glycosidic bond
- b) Phosphoester bond
- c) O-glycosidic bond
- d) Hydrogen bond
Answer: N-glycosidic bond
Question: Cytidine is a
- a) Nucleoside
- b) Nucleotide
- c) Nitrogen base
- d) Common dinucleotide in DNA and RNA
Answer: Nucleoside
Question: Which of the following process is related to reverse transcription?
- a) RNA dependent DNA synthesis
- b) RNA dependent polypeptide synthesis
- c) DNA dependent DNA synthesis
- d) DNA dependent RNA synthesis
Answer: RNA dependent DNA synthesis
Question: Which of the following structures are present in core particle of nucleosome?
- a) Octamer of histone proteins
- b) Non-histone proteins
- c) 200 bp of DNA
- d) Linker DNA
Answer: Octamer of histone proteins
Question: Packaging of DNA helix
- a) Is more complex in eukaryotes than prokaryotes
- b) Requires acidic proteins that help in coiling of DNA in prokaryotes
- c) Occurs with the help of NHC proteins only
- d) Involves polyamines in eukaryotes
Answer: Is more complex in eukaryotes than prokaryotes
Question: Length of DNA in E. coli is
- a) 1.36 mm
- b) 1.36 m
- c) 3.4 m
- d) 2.2 m
Answer: 1.36 mm
Question: Which of the following radioactive isotopes were utilised for labelling protein and DNA in transduction experiment respectively?
- a)
- b)
- c)
- d) None of these
Answer:
Question: Dominance of RNA world is proved by
- a) Splicing
- b) Polyadenylation
- c) All of these
- d) Capping
Answer: Splicing
Question: Which plant was used by Taylor to prove semiconservative replication at chromosomal level?
- a) Vicia faba
- b) Trillium
- c) Ophioglossum
- d) Haematoxylon
Answer: Vicia faba
Question: Unwinding of DNA creates tension which is released by enzyme
- a) Topoisomerase
- b) Primase
- c) Ligase
- d) Helicase
Answer: Topoisomerase
Question: During polymerisation of deoxyribonucleosides triphosphates in bacteria which of the following enzyme is mainly required?
- a) DNA dependent DNA polymerase
- b) DNA gyrase
- c) DNA dependent RNA polymerase
- d) RNA dependent DNA polymerase
Answer: DNA dependent DNA polymerase
Question: DNA polymerases catalyse polymerisation of / in
- a)
- b)
- c) Deoxyribonucleosides
- d) Ribonucleotides
Answer:
Question: During DNA replication which of the following does not act as substrates?
- a) dUTP
- b) dGTP
- c) dCTP
- d) dATP
Answer: dUTP
Question: Out of the two strands of DNA one is carrying genetic information for transcription and it is called
- a) Template strand
- b) Sense strand
- c) Non template strand
- d) Coding strand
Answer: Template strand
Question: When a mature mRNA was hybridised to its gene certain loops were observed. These loops represent
- a) Introns in DNA
- b) Introns in rRNA
- c) Exons in DNA
- d) Exons in tRNA
Answer: Introns in DNA
Question: Poly A tail is present in
- a) mRNA of eukaryotes
- b) Promotor of bacteria
- c) tRNA of eukaryotes
- d) mRNA of bacteria
Answer: mRNA of eukaryotes
Question: Find out the incorrect match
- a) UAG – Sense codon
- b) UGG – Tryptophan
- c) UUU – Phenylalanine
- d) GUG – Valine
Answer: UAG – Sense codon
Question: One codon codes for only one amino acid, hence the code is
- a) Unambiguous and specific
- b) Unambiguous and non-specific
- c) Ambiguous and non-specific
- d) Ambiguous and specific
Answer: Unambiguous and specific
Question: What is incorrect for UTR?
- a) Present in between the translational unit in mRNA
- b) Required for efficient translation process
- c) Not recognised by any tRNA
- d) Provide stability to mRNA
Answer: Present in between the translational unit in mRNA
Question: In bacteria, catalytic RNA is found in
- a) 50S subunit of ribosome
- b) 40S subunit of ribosome
- c) 60S subunit of ribosome
- d) 30S subunit of ribosome
Answer: 50S subunit of ribosome
Question: In lac operon, the regulator gene codes for
- a) Active repressor
- b) Inactive repressor
- c) Corepressor
- d) Aporepressor
Answer: Active repressor
Question: Mark the incorrect option w.r.t. lac operon
- a) Shows feed back repression
- b) Is under positive as well as negative control
- c) Controls catabolic pathway
- d) Discovered by Jacob and Monod
Answer: Shows feed back repression
Question: In lac operon, the lac mRNA
- a) Has several initiation and termination codons
- b) Is not transcribed in the presence of lactose
- c) Forms four different enzymes
- d) Is involved in an anabolic reaction
Answer: Has several initiation and termination codons
Question: How many locations have been identified in human genome where single base differences occur?
- a) 1.4 million
- b) 14 million
- c) 1.4 billion
- d) 14 billion
Answer: 1.4 million
Question: The non-human model organisms sequenced in Human Genome project were
- a) A nematode and fruit fly
- b) Fish and birds
- c) Wheat and rice
- d) Garden pea and fruit fly
Answer: A nematode and fruit fly
Question: Mark the correct one (w.r.t. application of DNA fingerprinting)
- a) More than one option is correct
- b) Determining the population diversity
- c) Forensic science
- d) Determining the genetic diversity
Answer: More than one option is correct
Question: What is incorrect for human chromosome 1?
- a) Its sequence was completed in May 2007
- b) It was the last chromosome to be sequenced
- c) It is one of the largest chromosome
- d) It has maximum number of genes
Answer: Its sequence was completed in May 2007
More Questions.......................................
Question: In the technique of DNA fingerprinting digestion of DNA is followed by
- a) Electrophoresis
- b) Hybridisation
- c) Denaturation
- d) Southern blotting
Answer: Electrophoresis
Question: In eukaryotes, RNA polymerase III catalyses the synthesis of
- a) 5 S rRNA, tRNA & SnRNA
- b) 28 S rRNA, 18 S rRNA & 5 S rRNA
- c) All types of rRNA & tRNA
- d) 28 S rRNA, 18 S rRNA & 5 S rRNA
Answer: 5 S rRNA, tRNA & SnRNA
Question: Read the following statements:
A. Variation at genetic level arises due to mutations.
B. Technique of DNA fingerprinting was initially developed by Alec Jeffreys
- a) Both (A) and (B) are correct
- b) Both (A) and (B) are incorrect
- c) Only (B) is correct
- d) Only (A) is correct
Answer: Both (A) and (B) are correct
Question: In DNA fingerprinting, detection of hybridised DNA fragments is possible by
- a) Autoradiography
- b) Centrifugation
- c) Blotting
- d) Electrophoresis
Answer: Autoradiography
Question: Mark the correct match
- a) VNTR – Intron
- b) Sanger method – Determination of amino acid sequences in proteins only
- c) Val operon – Found in eukaryotes
- d) None of these
Answer: VNTR – Intron
Question:
- a) C G A T G C A T
- b) A T G C A T C G
- c) A T C G T A C G
- d) T A C G T A G C
Answer: C G A T G C A T
Question: NHC structural proteins are
- a) Required for packaging of chromatin at higher levels
- b) Catalytic proteins rich in tryptophan and arginine
- c) Regulatory proteins
- d) Basic proteins rich in lysine, arginine
Answer: Required for packaging of chromatin at higher levels
Question: How many types of DNA polymerases are present in bacteria?
- a) Three
- b) Two
- c) One
- d) Five
Answer: Three
Question: Synthesis of leading and lagging strand require
- a) Single and many primers respectively
- b) Many primers
- c) Single primer
- d) Many and single primers respectively
Answer: Single and many primers respectively
Question: For the strand separation and stabilisation during DNA replication which of the following set of enzymes and proteins are required?
- a) Topoisomerase, helicase, SSBP
- b) Topoisomerase, helicase, ligase
- c) SSBP, gyrase, primase
- d) SSBP, gyrase, primase
Answer: Topoisomerase, helicase, SSBP
Question: In eukaryotes, the RNA polymerase that synthesises tRNA is RNA polymerase ______ and is also responsible for formation of ______ rRNA.
- a) III, 5 S
- b) II, 18 S
- c) I, 5 S
- d) II, 5.8 S
Answer: III, 5 S
Question: What is correct for bacterial transcription?
- a) Transcription and translation takes place in the same compartment
- b) Translation can begin when mRNA is fully transcribed
- c) mRNA requires processing to become active
- d) Rho factor initiates the process
Answer: Transcription and translation takes place in the same compartment
Question: Which of the following is not required during post transcriptional processing in eukaryotes?
- a) ScRNA
- b) Methyl guanosine triphosphate
- c) Ligase
- d) SnRNA
Answer: ScRNA
Question: Which of the following feature is correct for bacteria?
- a) DNA can be chromosomal as well as extrachromosomal
- b) Linear ss-DNA representing single chromosome
- c) DNA does not show coiling
- d) Presence of intervening sequences in DNA
Answer: DNA can be chromosomal as well as extrachromosomal
Question: In-vitro template independent RNA synthesis is a feature of
- a) Ochoa enzyme
- b) DNA polymerase
- c) Reverse transcriptase
- d) RNA polymerase
Answer: Ochoa enzyme
Question: In protein synthesis, which of the following are required for the synthesis of charged tRNA?
- a) Amino acid, ATP, Mg++, enzyme, tRNA
- b) Amino acid, GTP, initiation codon, ribosome
- c) Amino acid, ATP, K+, enzyme, mRNA
- d) Aminoacyl tRNA, ribosome, initiation codon, release factor
Answer: Amino acid, ATP, Mg++, enzyme, tRNA
Question: Termination of polypeptide synthesis in bacteria differs from eukaryotes in
- a) Involving more than one type of release factors
- b) Having different termination codons
- c) Being GTP dependent
- d) All of these
Answer: Involving more than one type of release factors
Question: The accessibility of promoter regions of bacterial DNA in many cases regulated by the interaction of proteins with sequences termed
- a) Operators
- b) Inhibitor genes
- c) Structural genes
- d) Regulators
Answer: Operators
Question: When the genomes of two people are cut using the same restriction enzyme, the length and number of fragments obtained are different, this is called
- a) RFLP
- b) PCR
- c) EST
- d) Northern blotting
Answer: RFLP
Question: Which of the following does not code for any proteins?
- a) More than one option is correct
- b) Mini-satellites
- c) Exons
- d) Micro-satellites
Answer: More than one option is correct
Question: Which statement is correct for homeotic genes?
- a) Control is exerted through homeodomain proteins
- b) Mutation in these genes not results in conversion of one body part into another
- c) Such genes have been studied extensively in humans
- d) Control oncogenesis process
Answer: Control is exerted through homeodomain proteins
Question: In which step of DNA profiling, nitrocellulose membrane is used?
- a) Blotting
- b) DNA amplification
- c) Autoradiography
- d) Denaturation
Answer: Blotting
Question: Repressor of lac-operon
- a) Is a tetrameric protein
- b) Has only one side
- c) Having a molecular weight of 16,000
- d) Is made by operator gene
Answer: Is a tetrameric protein
Question: Select the correct one (w.r.t. Wobble hypothesis)
- a) Third base can establish H-bonds even with the non complementary anticodon
- b) Third base of a codon lacks vibrating capacity
- c) Specificity of a anticodon is particularly determined by first two codon
- d) Major cause of degeneracy is the first two N-bases of codon
Answer: Third base can establish H-bonds even with the non complementary anticodon
Question: A set of genes or cDNA is immobilized on a glass slide and used in transcriptome studies is called
- a) Microarray
- b) DNA chip
- c) Genome
- d) Proteome
Answer: Microarray
Question: Which of the following bond is not present in DNA?
- a)
- b)
- c)
- d)
Answer:
Question: If there are 81 million bases in RNA of human cell, then calculate the total number of introns present in cDNA
- a) Zero
- b) Half the number of ribonucleotides
- c) Equal to ribonucleotides
- d) 27 millions
Answer: Zero
Question: Splicing is necessary for preparing a mature transcript and its movement to cytoplasm. It requires
- a) snRNA and proteins
- b) scRNA and snRNA
- c) scRNA only
- d) scRNA and proteins
Answer: snRNA and proteins
Question:
- a) Ribosomal binding loop
- b) AA - tRNA synthetase binding loop
- c) Nodoc site
- d) None of these
Answer: Ribosomal binding loop
Question:
- a) Two amino acids
- b) Three amino acids
- c) Six amino acids
- d) Five amino acids
Answer: Two amino acids
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