• Symptoms include benign, hard outgrowths with horny surface ( warts) over the skin and mucosal surface of external genitalia and perianal area.
• It spreads through sexual intercourse with carriers of the viruses of this disease.
• Dianosis is done by clinical symptoms, antibody detection, culture and DNA hybridization.
• Cryosurgery is used in removal of warts podophyllum preparations and podofilon are useful in treatment. Imiquim and interferon inducer is also useful.
(8) Chlamydiasis
• Chalamydiasis is caused by Chlamydia trachomatis.
• Chlamydia causes urethritis, epididymitis, mucopurulent, cervicitis, inflammation of fallopian tube, proctitis crectal pain with mucus and occasional bleeding etc.
• It spreads by sexual contact with infected mating partner.
• Incubation period is about one week.
• It is diagnosed by Gram-staining of discharge, antigen detection and nucleic acid hybridization.
• Antibiotics like tetracycline, erythromycin and rifampacin are effective in treatment.
(9) Lymphogranuloma venerlum
• Ltmphogranuloma venerlum is caused by chlamydia trachomatis of L1, L2, L3 stereotypes.
• Symptoms include cutaneous or mucosal genital lesion, urithritis or endocervictis and genital elephantiasis.
• It is diagnosed by Gram negative discharge, antigen detection, microscopic examination of scraping and nuclei acid hybridization.
• It spreads by sexual contact.
• Antibiotics tetracycline, doxycycline erythromycin and azithromycin are used for treatment.
(10) Trichomoniasis
• Trichomoniasis is caused by Trichomonasis vaginalis
• The parasite affects both males and females.
• In females it causes vaginitis with foul smelling, yellow vaginal discharge and burning sensation. In males, it causes urethritis, epididymitis and prostatitis resulting in pain and burning sensations.
• It is transmitted through sexual intercourse.
• It is diagnosed by microscopic examination, culture and immunofluorescent antibody staining.
• It can be treated by metronidazole.
(11) Scabies
• Scabies is caused by Sarcoptes csabiei.
• Its symptoms include painful itching and red patches on the skin of pubic region.
• The parasite is transmitted by intimate contact or by sharing cloth, sheets and blankets etc.
(12) Pediculosis pubis
• Pediculosis pubis is caused by Phthirus pubis ( Parasitic louse).
• Its symptoms include painful itching and red patches on the skin of pubic region.
• The parasite is transmitted by intimate contact or by sharing clothes, sheets and blankets etc.
• Medical shampoos are recommended for treatment.
(13) Candidiasis
• Candidasis is caused by fungus Candida albicans ( Vaginal yeast).
• Women with yeast infections experience painful inflammation of vagina often with a thick cheesy discharge.
• Man may develop a painful inflammation of the urethra through sexual contact with an infected woman.
• Antibiotics such as clotrimazole, miconazole and nystatin are used for the treatment.
INFERTILITY
• Inability to conceive or produce children inspite of unprotected sexual cohabitation is called infertility.
• It is caused by various reasons which can be grouped under Physical, Congenital, immunological or even psychological disorders.
• Specialized infertility clinics can help in the diagnosis and proper treatment of some of these disorders and enable these couples to have children.
• However, were such diagnosis and treatment are not possible, the couples can be assisted to have children through certain special techniques called assisted reproductive techniques ( ART)
Assisted Reproductive Technologies ( ART)
Assisted reproductive technologies(ART) include a number of special techniques which assist infertile couples to have children.
Some important are
(1) Test tube baby programme
(2) Artificial insemination technique
(3) Gamete intra fallopian transfer
(4) Intracytoplasmic sperm injection
I) Test tube baby programme
• The baby produced by conceiving in a culture dish and nursing in the uterus is called a test tube baby.
• This method involves in vitro fertilization (IVF) i.e. fertilization of male and female gametes outside the body in almost similar conditions as that in the body followed by Embryo Transfer ( ET ).
• Embryo upto 8 Blastomeres is transferred into the fallopian tube ( ZIFT – zygote Intra Fallopian Transfer) to complete its further development.
• If the embryo is with more than 8 blastomers, it is transferred into uterus ( IUT – Intra Uteriane Transfer) to complete its further development.
• A developing embryo can be inserted in the uterus of another female.
A woman who substitutes or takes the place of the real mother to nurse the embryo is called surrogate mother or genetic mother
• The success rate of the technique of producing test tube babies is less than 20%. In India, the first test tube baby was born on August 6, 1986 at K.E.M Hospital, Mumbai. She was named kum. Harsha. The doctor was Indira Hinduja
(II) Artificial Insemination Technique ( AIT)
• AIT is used in those females where the husband is either unable to inseminate the female or has very low sperm counts in the ejaculation.
• In this technique the semen collected either from the husband or a healthy donor is artificially introduced into the vagina or into the uterus of the female.
(III) Gamete Intra Fallopian Transfer ( GIFT)
• This method is used in females who cannot produce ova but can provide suitable environment for fertilization and further development of embryo in the oviducts
• In this technique, ovum from the donor female is surgically removed and then introduce into the fallopian tube of females incapable of producing ovum for fertilization
(IV) Intra Cytoplasmic Sperm Injection ( ICSI)
• In this technique sperm is directly injected into the ovum to form an embryo in the laboratory
• The embryo is later transferred by ZIFT or IUT in woman
DETECTION OF FOETAL DISORDERS DURING EARLY PREGNANCY
Foetal disorders during early pregnancy can be detected by following techniques
• Amniocentesis
• Chorionic Villi Sampling (CVS)
• Non-invasive techniques
• Foetoscopy
(I) Amniocentesis
• Amniocentesis is a foetal sex determination and disorder test based on the chromosomal pattern in the amniotic fluid surrounding the developing embryo
• Then a small amount of amniotic fluid is drawn by passing special surgical syringe needle in to the abdominal wall and uterine wall into the amniotic sac containing amniotic fluid.
• These cells are cultured and are used to determine chromosomal abnormalities.
• Unfortunately, this useful technique is being misused to kill the normal female foetuses. It has been legally banned for the determination of sex to avoid female foeticide.
(II) Chorionic Villi Sampling ( CVS)
• In this technique the physician inserts a narrow, flexible tube through the mother’s vagina and cervix into the uterus and withdraws a small amount of foetal tissue from the placenta.
• It is advantageous over amniocentesis in its speed and also that it can be performed early, between 8th and 10th week of pregnancy.
(III) Non-invasive technique
• One of the widely used non-invasive technique to determine foetal condition is ultra sound imaging.
• Another technique is based on the fact that a few foetal blood cells leak across the placenta into the mother’s blood stream. A blood sample from the mother provides enough foetal cells that can be tested for genetic disorders.
(IV) Foetoscopy
Foetoscopy is another technique in which a needle-thin to be containing a viewing scope is inserted into the uterus, giving the physician a direct view of the foetus.